Targeted therapies for gastroesophageal cancers
نویسندگان
چکیده
منابع مشابه
Combinations of targeted therapies in human cancers
human cancers are driven by one specific molecular event, such as, for example, chronic myeloid leukemia. Human cancers appear to be generally derived from multiple oncogenic alterations maturing through their own particular mechanisms [1]. One major consequence of such alterations is the dysregulation of intracellular signaling pathways favoring tumor cell survival, proliferation, and motility...
متن کاملTargeted therapy in gastroesophageal cancers: past, present and future
Gastroesophageal cancer is a significant global problem that frequently presents at an incurable stage and has very poor survival with standard chemotherapy approaches. This review will examine the epidemiology and molecular biology of gastroesophageal cancer and will focus on the key deregulated signaling pathways that have been targeted in the clinic. A comprehensive overview of clinical data...
متن کاملMolecularly targeted therapies in head and neck cancers.
Head and neck cancers (HNC) are 6th most common malignancies according to the incidence rate. Over 85% of tumors of this region are epithelial tumors, especially squamous cell carcinomas (head and neck squamous cell carcinomas - HNSCC). Surgery, chemotherapy and radiotherapy are still the standard for the treatment of HNC. Despite the great development of the various methods of treatment, survi...
متن کاملMolecular Panel Testing of Cancers to Identify Targeted Therapies
Currently, there is interest in treating cancers by targeting biological “pathways” that are characterized by specific genetic markers. Genetic panel testing offers the potential to evaluate a large number of genetic markers at a single time to identify treatments that target specific pathways. There are some individual markers that have established benefit in certain types of cancers; these si...
متن کاملTargeted therapies in the treatment of colorectal cancers.
BACKGROUND In solid organ malignancies, no tumor type has seen a greater impact from the development of novel targeted therapies in 2004 than metastatic colorectal cancer. METHODS We review the current progress to date with the use of monoclonal antibodies in colorectal cancer and look at newer therapies under investigation. RESULTS Two monoclonal antibodies received Food and Drug Administr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2020
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm-20-3265